Accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, compressed sensing, and k-space weighted image contrast reconstruction tailored for visual analysis and quantification of myocardial blood flow

Nivedita K. Naresh, Hassan Haji-Valizadeh, Pascale J. Aouad, Matthew J. Barrett, Kelvin Chow, Ann B. Ragin, Jeremy D. Collins, James C. Carr, Daniel C. Lee, Daniel Kim

Research output: Contribution to journalArticle

Abstract

Purpose: To develop an accelerated cardiac perfusion pulse sequence and test whether it is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of myocardial blood flow (MBF). Methods: We implemented an accelerated first-pass cardiac perfusion pulse sequence by combining radial k-space sampling, compressed sensing (CS), and k-space weighted image contrast (KWIC) filtering. The proposed and clinical standard pulse sequences were evaluated in a randomized order in 13 patients at rest. For visual analysis, 3 readers graded the conspicuity of wall enhancement, artifact, and noise level on a 5-point Likert scale (overall score index = sum of 3 individual scores). Resting MBF was calculated using a Fermi function model with and without KWIC filtering. Mean visual scores and MBF values were compared between sequences using appropriate statistical tests. Results: The proposed pulse sequence produced greater spatial coverage (6–8 slices) with higher spatial resolution (1.6 × 1.6 × 8 mm3) and shorter readout duration (78 ms) compared to clinical standard (3–4 slices, 3 × 3 × 8 mm3, 128 ms, respectively). The overall image score index between accelerated (11.1 ± 1.3) and clinical standard (11.2 ± 1.3) was not significantly different (P = 0.64). Mean resting MBF values with KWIC filtering (0.9–1.2 mL/g/min across different slices) were significantly lower (P < 0.0001) than those without KWIC filtering (3.1–4.3 mL/g/min) and agreed better with values reported in literature. Conclusion: An accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, CS, and KWIC filtering is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of MBF.

LanguageEnglish (US)
JournalMagnetic resonance in medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Computer-Assisted Image Processing
Perfusion
Artifacts
Noise

Keywords

  • cardiac perfusion
  • MRI
  • quantitative perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, compressed sensing, and k-space weighted image contrast reconstruction tailored for visual analysis and quantification of myocardial blood flow. / Naresh, Nivedita K.; Haji-Valizadeh, Hassan; Aouad, Pascale J.; Barrett, Matthew J.; Chow, Kelvin; Ragin, Ann B.; Collins, Jeremy D.; Carr, James C.; Lee, Daniel C.; Kim, Daniel.

In: Magnetic resonance in medicine, 01.01.2018.

Research output: Contribution to journalArticle

Naresh, Nivedita K. ; Haji-Valizadeh, Hassan ; Aouad, Pascale J. ; Barrett, Matthew J. ; Chow, Kelvin ; Ragin, Ann B. ; Collins, Jeremy D. ; Carr, James C. ; Lee, Daniel C. ; Kim, Daniel. / Accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, compressed sensing, and k-space weighted image contrast reconstruction tailored for visual analysis and quantification of myocardial blood flow. In: Magnetic resonance in medicine. 2018.
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abstract = "Purpose: To develop an accelerated cardiac perfusion pulse sequence and test whether it is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of myocardial blood flow (MBF). Methods: We implemented an accelerated first-pass cardiac perfusion pulse sequence by combining radial k-space sampling, compressed sensing (CS), and k-space weighted image contrast (KWIC) filtering. The proposed and clinical standard pulse sequences were evaluated in a randomized order in 13 patients at rest. For visual analysis, 3 readers graded the conspicuity of wall enhancement, artifact, and noise level on a 5-point Likert scale (overall score index = sum of 3 individual scores). Resting MBF was calculated using a Fermi function model with and without KWIC filtering. Mean visual scores and MBF values were compared between sequences using appropriate statistical tests. Results: The proposed pulse sequence produced greater spatial coverage (6–8 slices) with higher spatial resolution (1.6 × 1.6 × 8 mm3) and shorter readout duration (78 ms) compared to clinical standard (3–4 slices, 3 × 3 × 8 mm3, 128 ms, respectively). The overall image score index between accelerated (11.1 ± 1.3) and clinical standard (11.2 ± 1.3) was not significantly different (P = 0.64). Mean resting MBF values with KWIC filtering (0.9–1.2 mL/g/min across different slices) were significantly lower (P < 0.0001) than those without KWIC filtering (3.1–4.3 mL/g/min) and agreed better with values reported in literature. Conclusion: An accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, CS, and KWIC filtering is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of MBF.",
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AU - Haji-Valizadeh, Hassan

AU - Aouad, Pascale J.

AU - Barrett, Matthew J.

AU - Chow, Kelvin

AU - Ragin, Ann B.

AU - Collins, Jeremy D.

AU - Carr, James C.

AU - Lee, Daniel C.

AU - Kim, Daniel

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AB - Purpose: To develop an accelerated cardiac perfusion pulse sequence and test whether it is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of myocardial blood flow (MBF). Methods: We implemented an accelerated first-pass cardiac perfusion pulse sequence by combining radial k-space sampling, compressed sensing (CS), and k-space weighted image contrast (KWIC) filtering. The proposed and clinical standard pulse sequences were evaluated in a randomized order in 13 patients at rest. For visual analysis, 3 readers graded the conspicuity of wall enhancement, artifact, and noise level on a 5-point Likert scale (overall score index = sum of 3 individual scores). Resting MBF was calculated using a Fermi function model with and without KWIC filtering. Mean visual scores and MBF values were compared between sequences using appropriate statistical tests. Results: The proposed pulse sequence produced greater spatial coverage (6–8 slices) with higher spatial resolution (1.6 × 1.6 × 8 mm3) and shorter readout duration (78 ms) compared to clinical standard (3–4 slices, 3 × 3 × 8 mm3, 128 ms, respectively). The overall image score index between accelerated (11.1 ± 1.3) and clinical standard (11.2 ± 1.3) was not significantly different (P = 0.64). Mean resting MBF values with KWIC filtering (0.9–1.2 mL/g/min across different slices) were significantly lower (P < 0.0001) than those without KWIC filtering (3.1–4.3 mL/g/min) and agreed better with values reported in literature. Conclusion: An accelerated, first-pass cardiac perfusion pulse sequence with radial k-space sampling, CS, and KWIC filtering is capable of increasing spatial coverage, generating high-quality images, and enabling quantification of MBF.

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KW - MRI

KW - quantitative perfusion

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